Endocrine Abstracts

Introduction: To date, several mutations have been identified as the underlying cause of hypogonadotropic hypogonadism. However, they account for a small minority of cases, suggesting that other genes play a significant role in the pathogenesis. The aim of the present study was to examine the prevalence of KAL1, GnRH1, GnRHR, PROK2 and PROKR2 mutations. Because it has several advantages over traditional screening methods, multiplex ligation dependent probe amplification (MLPA)...

Introduction: Visceral adipose tissue (VAT) is closely related to metabolic derangement, such as dyslipidemia insulin resistance and type 2 diabetes. Also, there is an increase in deposition of visceral adipose tissue in hypogonadal subjects. The visceral adiposity index (VAI) is a sex-specific mathematical index, based on waist circumference (WC), body mass index (BMI), triglycerides (TG) and HDL cholesterol (HDL) levels, indirectly expressing visceral adipose function. We in...

Objective: The relationship between metabolic syndrome (MS) and hypogonadism has always been investigated in study groups confounded with aging, obesity or chronic metabolic disorders. So far there has been no data about the presence of MS in young hypogonadal patients. Also there is controversial data about the metabolic effects of testosteron replacement therapy. We investigated the frequency of MS in treatment naïve, young men with congenital hypogonadal hypogonadism (...